Chapter 5

Tissues, skin, and contact with an object

A good fit in CAD does not establish a suitable interface with a person

Human Biology for the Medical Maker

Why this chapter exists

  • The most common serious harm from a maker's contact object
  • Almost always caused by someone competent
  • A well-machined splint with a crisp edge
  • A moulded handle with its parting line across the point of highest load
  • A strap sized in the morning on a limb that swells by afternoon

The four tissue families

  • Epithelial: covering, lining, barrier
  • Connective: support, defined by its matrix
  • Muscle: generates force
  • Nervous: communication and control

Epithelium — two facts with design consequences

  • Named by cell shape and layers: simple squamous in alveoli, stratified in skin
  • Avascular: fed by diffusion from the connective tissue beneath
  • Damage to the layer beneath is what causes real trouble
  • A continuous epithelium is the primary barrier
  • Breach it — even a 3 mm pressure break — and it becomes a wound project

Connective tissue: the engineer's family

Matrix componentMechanical roleAnalogy and its limit
CollagenHigh tensile strength, low stretchAramid fibre — but living and remodelling
ElastinLarge recoverable strainRubber — interwoven so stiffness rises sharply
Ground substanceBinds water, resists compressionA hydrogel — fluid flow makes it time-dependent

The tissues a maker confuses

TissueConnectsDo not model it as…
TendonMuscle to boneThe motor — it transmits; it does not generate
LigamentBone to boneA tendon — different job and place
Articular cartilageCovers bone endsA rubber pad — its load-bearing is fluid pressure
FibrocartilageDiscs, menisciSolid
FatBeneath skinA uniform layer of known thickness
BoneThe skeletonInert — it remodels with load

Simplify — and label the simplification. "Cord represents a tendon; the demonstrator supplies the muscle force."

Skin is an organ

A layered composite with active biology, not a cladding material

The layers of skin

  • Epidermis: 0.05 to 0.1 mm, no blood vessels, renewed in about a month
  • Dermis: 1 to 4 mm; vessels, nerves, glands, collagen
  • Hypodermis: fat; thickness varies tenfold
  • Bony prominences concentrate load deep

The epidermis and its barrier

  • Keratinocytes form the barrier; Langerhans cells keep watch
  • Melanocyte number is similar across populations; melanin amount differs
  • That matters for optical sensors — see the pulse oximeter
  • Strip the stratum corneum and the barrier fails before any wound is visible
  • Medical adhesive-related skin injury is a design-caused harm

What skin does — and what that means for a design

FunctionConsequence
BarrierAny breach changes the project; adhesive, resin, dye, or nickel is a chemical exposure
SensationDiscomfort is a safety mechanism — absent if sensation is reduced
ThermoregulationCovering skin is a thermal and microclimate decision
Water balanceOcclusion macerates and weakens skin

Pressure is only the beginning

Distribution, depth, time, the person, and movement

Average pressure: a true and useful calculation

20 kPa

20 newtons over 10 square centimetres — about 150 mmHg

Use p = F/A to ask about force distribution. Never to invent a clinical threshold.

What the pressure calculation cannot establish

  • Distribution — a ridge, seam, or fastener head carries the peak
  • Depth — damage often starts near bone, before the surface shows it
  • Time — load and duration trade off non-linearly
  • The person — perfusion, age, moisture, sensation, mobility
  • Movement — sliding adds shear and friction

Pressure, friction, shear, and microclimate

  • Pressure: compresses tissue; can occlude vessels
  • Friction: abrades the surface; blisters
  • Shear: layers slide; deep vessels kink; surface may look normal
  • Microclimate: moisture macerates; heat raises demand

Soft tissue is not a metal

PropertyWhy you care
Non-linear J-curveNo single modulus; low-strain stiffness underestimates
ViscoelasticCreep and relaxation: a strap at 9am is different at 11am
AnisotropicA symmetric part is not symmetric in its effect
Pre-stressedExcised tissue data does not transfer to the living body
AdaptiveThe tissue in week six is not the tissue in week one

Stiffness, for intuition only

MaterialApproximate modulus
Fat1 to 10 kPa
Skin0.1 to 100 MPa depending on strain
Silicone elastomer0.1 to 10 MPa
Rigid polymers — acetal, ABS, PLA, nylon1 to 4 GPa
Tendon1 to 2 GPa
Cortical bone10 to 20 GPa
Stainless steelabout 200 GPa

Every rigid object is much harder than what it touches. The compliance mismatch is where load concentrates.

Inflammation and repair

  • Haemostasis — minutes: clot and platelet plug
  • Inflammation — hours to days: redness, heat, swelling, pain
  • Proliferation — days to weeks: new vessels and collagen
  • Remodelling — weeks to months, or longer
  • Swelling changes dimensions within hours
  • Scar is not replacement

Preventing a 5 mm skin break matters more than being good at responding to one.

Engineering bridge: the contact category decides who reviews

CategoryExampleImplies
No body contactTabletop model, bench fixture, softwareWorkshop review; cleaning for handling
Intact skin, briefHandle or control used for minutesHuman factors: edges, forces, cleaning
Intact skin, prolongedSplint, strap, seating, worn deviceClinical assessment — not a maker decision alone
Compromised skinFragile, swollen, scarred, reddenedSpecialist clinical involvement, always
Breached, mucosa, internalWound, airway, implantA different universe — not a learning project

A contact design checklist

The contact

  • Where, over what area, for how long?
  • What forces, in which directions?
  • Is the skin intact? Who assessed it?
  • What is beneath — bone, nerve, vessel?
  • Does the limb change size?

The object and its life

  • Edges, seams, parting lines, fasteners?
  • Can the user feel and act on discomfort?
  • How is it cleaned, and who re-checks it?
  • What happens when it fails? How is it removed?
  • Does a product already exist?

Design moves, and what each one costs

MoveIntended effectWhat it also does
Increase areaLower average pressureBulk, new edges, more trapped moisture
Add paddingDistribute loadChanges grip, adds seams, absorbs fluid, hides a hard edge
Round the edgesRemove stress concentrationAlmost always good
Softer materialLess compliance mismatchMay lose the function that justified the part
Make it adjustableAccommodate swellingCan be set wrongly; new failure modes
Change the methodRemove a process featureCost, lead time, cleanability change

Write it honestly: "this changes X, and I have not established Y."

Clinical devices and software in this area

Devices

  • Dressings: moisture management
  • Negative pressure wound therapy: pump, seal, alarms
  • Pressure-redistribution surfaces; pressure mapping
  • Compression; orthoses; slide sheets; seating

Software

  • Wound imaging and measurement apps
  • Risk scores — a prompt, not a prediction
  • AI lesion triage: skin-tone diversity is a known gap
  • Orthotic CAD and 3D scanning

Training technology — and the maker's entry point

  • Suture and skin pads: layered silicone, consumed by the hundred
  • Moulage and wound-care trainers
  • Instrumented interface rigs: force sensors under cast silicone
  • Sewn demonstration straps that vary one thing each

The skill is mould making — and making the hundredth pad match the first.

Worked example: the awkward handle

MechanismEvidenceFix direction
Force at an edge or seamMark or pain at a lineRadius, redistribute, move the seam
Too little areaDiffuse pressureLarger, contoured
Awkward wrist positionPain in wrist or forearmChange the angle
Excessive grip forceMuscle fatigueReduce force needed
SlippingGripping harder than neededFriction, retaining feature
Heat or moistureClammy; worse when warmMaterial and ventilation

For three of these, padding makes it worse. Find the mechanism; don't apply the default fix.

Workshop exercise and exit criteria

  • Build a layered skin model — label it schematic, not to scale
  • Compare a narrow and a broad contact; mark where seams concentrate force
  • Demonstrate shear with foam sheets — and list how it is unlike skin
  • Draw a contact map for the elbow model

Do not run pressure or prolonged-contact experiments on yourself or anyone else.

What this chapter does not establish

  • You cannot set a pressure limit
  • You cannot assess anyone's skin
  • A bench interface-pressure measurement is not a safety assessment
  • "Skin-safe" needs evidence about a finished object in a specific use
  • No part of this authorises prolonged-contact or wound-contact work

Next — Bones, joints, and movement.